학술논문
Runt related transcription factor-1 plays a central role in vessel co-option of colorectal cancer liver metastases
Document Type
article
Author
Source
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Subject
Language
English
ISSN
2399-3642
Abstract
Miran Rada et al. identify a key role for RUNX1 in liver metastasis of colorectal cancer. They show that RUNX1 is necessary for driving blood vessel co-option from surrounding liver tissue and that regulation of this process relies on a signaling feedback loop between RUNX1 transcriptional target TSP1 in tumor cells and TGFβ1 in the liver.