학술논문
The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol
Document Type
article
Author
Paul M. Vespa; Vikesh Shrestha; Nicholas Abend; Denes Agoston; Alicia Au; Michael J. Bell; Thomas P. Bleck; Manuel Buitrago Blanco; Jan Claassen; Ramon Diaz-Arrastia; Dominique Duncan; Ben Ellingson; Brandon Foreman; Emily J. Gilmore; Lawrence Hirsch; Martin Hunn; Alaa Kamnaksh; David McArthur; Andrew Morokoff; Terrence O'Brien; Kristine O'Phelan; Courtney L. Robertson; Eric Rosenthal; Richard Staba; Arthur Toga; Frederick A. Willyerd; Lara Zimmermann; Elisa Yam; Susana Martinez; Courtney Real; Jerome Engel, Jr
Source
Neurobiology of Disease, Vol 123, Iss , Pp 110-114 (2019)
Subject
Language
English
ISSN
1095-953X
Abstract
The Epilepsy Bioinformatics Study for Anti-epileptogenic Therapy (EpiBioS4Rx) is a longitudinal prospective observational study funded by the National Institute of Health (NIH) to discover and validate observational biomarkers of epileptogenesis after traumatic brain injury (TBI). A multidisciplinary approach has been incorporated to investigate acute electrical, neuroanatomical, and blood biomarkers after TBI that may predict the development of post-traumatic epilepsy (PTE). We plan to enroll 300 moderate-severe TBI patients with a frontal and/or temporal lobe hemorrhagic contusion. Acute evaluation with blood, imaging and electroencephalographic monitoring will be performed and then patients will be tracked for 2 years to determine the incidence of PTE. Validation of selected biomarkers that are discovered in planned animal models will be a principal feature of this work. Specific hypotheses regarding the discovery of biomarkers have been set forth in this study. An international cohort of 13 centers spanning 2 continents will be developed to facilitate this study, and for future interventional studies.