학술논문

Emerging roles for the autophagy machinery in extracellular vesicle biogenesis and secretion
Document Type
article
Source
FASEB BioAdvances, Vol 3, Iss 5, Pp 377-386 (2021)
Subject
Biology (General)
QH301-705.5
Language
English
ISSN
2573-9832
2020-0013
Abstract
Abstract Autophagy classically functions to maintain cell health during stressful conditions by targeting cytosolic components for degradation and recycling via lysosomal pathways. However, accumulating evidence also supports roles for autophagy‐related genes (ATGs) in non‐degradative processes including cellular secretion. Here, we review emerging roles for the autophagy machinery in regulating extracellular vesicle loading and secretion and discuss how functional coupling of these pathways may impact normal physiology and disease.