학술논문
Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection
Document Type
article
Author
Bo Li; Sara M. Clohisey; Bing Shao Chia; Bo Wang; Ang Cui; Thomas Eisenhaure; Lawrence D. Schweitzer; Paul Hoover; Nicholas J. Parkinson; Aharon Nachshon; Nikki Smith; Tim Regan; David Farr; Michael U. Gutmann; Syed Irfan Bukhari; Andrew Law; Maya Sangesland; Irit Gat-Viks; Paul Digard; Shobha Vasudevan; Daniel Lingwood; David H. Dockrell; John G. Doench; J. Kenneth Baillie; Nir Hacohen
Source
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Here, Li et al. perform a genome-wide CRISPR screen to identify host dependency factors for influenza A virus infection and show that the host mRNA cap methyltransferase CMTR1 is important for viral cap snatching and that it affects expression of antiviral genes.