학술논문
Leveraging longitudinal diffusion MRI data to quantify differences in white matter microstructural decline in normal and abnormal aging
Document Type
article
Author
Derek B. Archer; Kurt Schilling; Niranjana Shashikumar; Varuna Jasodanand; Elizabeth E. Moore; Kimberly R. Pechman; Murat Bilgel; Lori L. Beason‐Held; Yang An; Andrea Shafer; Luigi Ferrucci; Shannon L. Risacher; Katherine A. Gifford; Bennett A. Landman; Angela L. Jefferson; Andrew J. Saykin; Susan M. Resnick; Timothy J. Hohman; for the Alzheimer's Disease Neuroimaging Initiative
Source
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 4, Pp n/a-n/a (2023)
Subject
Language
English
ISSN
2352-8729
Abstract
Abstract Introduction It is unclear how rates of white matter microstructural decline differ between normal aging and abnormal aging. Methods Diffusion MRI data from several well‐established longitudinal cohorts of aging (Alzheimer's Disease Neuroimaging Initiative [ADNI], Baltimore Longitudinal Study of Aging [BLSA], Vanderbilt Memory & Aging Project [VMAP]) were free‐water corrected and harmonized. This dataset included 1723 participants (age at baseline: 72.8 ± 8.87 years, 49.5% male) and 4605 imaging sessions (follow‐up time: 2.97 ± 2.09 years, follow‐up range: 1–13 years, mean number of visits: 4.42 ± 1.98). Differences in white matter microstructural decline in normal and abnormal agers was assessed. Results While we found a global decline in white matter in normal/abnormal aging, we found that several white matter tracts (e.g., cingulum bundle) were vulnerable to abnormal aging. Conclusions There is a prevalent role of white matter microstructural decline in aging, and future large‐scale studies in this area may further refine our understanding of the underlying neurodegenerative processes. HIGHLIGHTS Longitudinal data were free‐water corrected and harmonized. Global effects of white matter decline were seen in normal and abnormal aging. The free‐water metric was most vulnerable to abnormal aging. Cingulum free‐water was the most vulnerable to abnormal aging.