학술논문
The transcriptional landscape of Shh medulloblastoma
Document Type
article
Author
Patryk Skowron; Hamza Farooq; Florence M. G. Cavalli; A. Sorana Morrissy; Michelle Ly; Liam D. Hendrikse; Evan Y. Wang; Haig Djambazian; Helen Zhu; Karen L. Mungall; Quang M. Trinh; Tina Zheng; Shizhong Dai; Ana S. Guerreiro Stucklin; Maria C. Vladoiu; Vernon Fong; Borja L. Holgado; Carolina Nor; Xiaochong Wu; Diala Abd-Rabbo; Pierre Bérubé; Yu Chang Wang; Betty Luu; Raul A. Suarez; Avesta Rastan; Aaron H. Gillmor; John J. Y. Lee; Xiao Yun Zhang; Craig Daniels; Peter Dirks; David Malkin; Eric Bouffet; Uri Tabori; James Loukides; François P. Doz; Franck Bourdeaut; Olivier O. Delattre; Julien Masliah-Planchon; Olivier Ayrault; Seung-Ki Kim; David Meyronet; Wieslawa A. Grajkowska; Carlos G. Carlotti; Carmen de Torres; Jaume Mora; Charles G. Eberhart; Erwin G. Van Meir; Toshihiro Kumabe; Pim J. French; Johan M. Kros; Nada Jabado; Boleslaw Lach; Ian F. Pollack; Ronald L. Hamilton; Amulya A. Nageswara Rao; Caterina Giannini; James M. Olson; László Bognár; Almos Klekner; Karel Zitterbart; Joanna J. Phillips; Reid C. Thompson; Michael K. Cooper; Joshua B. Rubin; Linda M. Liau; Miklós Garami; Peter Hauser; Kay Ka Wai Li; Ho-Keung Ng; Wai Sang Poon; G. Yancey Gillespie; Jennifer A. Chan; Shin Jung; Roger E. McLendon; Eric M. Thompson; David Zagzag; Rajeev Vibhakar; Young Shin Ra; Maria Luisa Garre; Ulrich Schüller; Tomoko Shofuda; Claudia C. Faria; Enrique López-Aguilar; Gelareh Zadeh; Chi-Chung Hui; Vijay Ramaswamy; Swneke D. Bailey; Steven J. Jones; Andrew J. Mungall; Richard A. Moore; John A. Calarco; Lincoln D. Stein; Gary D. Bader; Jüri Reimand; Jiannis Ragoussis; William A. Weiss; Marco A. Marra; Hiromichi Suzuki; Michael D. Taylor
Source
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Sonic Hedgehog medulloblastoma (Shh-MB) comprises four subtypes each with distinct clinical traits. Here the authors characterize the genome, transcriptome, and methylome of Shh-MB subtypes, revealing a complex fusion landscape and the molecular convergence of MYCN and cAMP signaling pathways.