학술논문
Hypoxia in astrocytic tumors and implications for therapy
Document Type
article
Author
Source
Neurobiology of Disease, Vol 85, Iss , Pp 227-233 (2016)
Subject
Language
English
ISSN
1095-953X
Abstract
Glioblastoma (GBM, Grade IV astrocytoma) is the most common and most aggressive of the primary malignant brain tumors in adults. Hypoxia is a distinct feature in GBM and plays a significant role in tumor progression, resistance to treatment and poor outcomes. This review considers the effects of hypoxia on astrocytic tumors and the mechanisms that contribute to tumor progression and therapeutic resistance, with a focus on the vascular changes, chemotaxic signaling pathways and metabolic alterations involved.