학술논문
Inflammasome activation controlled by the interplay between post-translational modifications: emerging drug target opportunities
Document Type
article
Source
Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-12 (2021)
Subject
Language
English
ISSN
1478-811X
Abstract
Abstract Controlling the activation of the NLRP3 inflammasome by post-translational modifications (PTMs) of critical protein subunits has emerged as a key determinant in inflammatory processes as well as in pathophysiology. In this review, we put into context the kinases, ubiquitin processing and other PTM enzymes that modify NLRP3, ASC/PYCARD and caspase-1, leading to inflammasome regulation, activation and signal termination. Potential target therapeutic entry points for a number of inflammatory diseases focussed on PTM enzyme readers, writers and erasers, leading to the regulation of inflammasome function, are discussed. Video Abstract