학술논문
Super-enhancer-based identification of a BATF3/IL-2R−module reveals vulnerabilities in anaplastic large cell lymphoma
Document Type
article
Author
Huan-Chang Liang; Mariantonia Costanza; Nicole Prutsch; Mark W. Zimmerman; Elisabeth Gurnhofer; Ivonne A. Montes-Mojarro; Brian J. Abraham; Nina Prokoph; Stefan Stoiber; Simone Tangermann; Cosimo Lobello; Jan Oppelt; Ioannis Anagnostopoulos; Thomas Hielscher; Shahid Pervez; Wolfram Klapper; Francesca Zammarchi; Daniel-Adriano Silva; K. Christopher Garcia; David Baker; Martin Janz; Nikolai Schleussner; Falko Fend; Šárka Pospíšilová; Andrea Janiková; Jacqueline Wallwitz; Dagmar Stoiber; Ingrid Simonitsch-Klupp; Lorenzo Cerroni; Stefano Pileri; Laurence de Leval; David Sibon; Virginie Fataccioli; Philippe Gaulard; Chalid Assaf; Fabian Knörr; Christine Damm-Welk; Wilhelm Woessmann; Suzanne D. Turner; A. Thomas Look; Stephan Mathas; Lukas Kenner; Olaf Merkel
Source
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Anaplastic large cell lymphoma (ALCL) is an aggressive T-cell lymphoma often with poor prognosis. To identify genes defining ALCL cell state and dependencies, the authors here characterize ALCL-specific super-enhancers and describe the BATF3/IL-2R−module as a therapeutic opportunity for ALCL.