학술논문
A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers
Document Type
article
Author
Juliette Coignard; Michael Lush; Jonathan Beesley; Tracy A. O’Mara; Joe Dennis; Jonathan P. Tyrer; Daniel R. Barnes; Lesley McGuffog; Goska Leslie; Manjeet K. Bolla; Muriel A. Adank; Simona Agata; Thomas Ahearn; Kristiina Aittomäki; Irene L. Andrulis; Hoda Anton-Culver; Volker Arndt; Norbert Arnold; Kristan J. Aronson; Banu K. Arun; Annelie Augustinsson; Jacopo Azzollini; Daniel Barrowdale; Caroline Baynes; Heko Becher; Marina Bermisheva; Leslie Bernstein; Katarzyna Białkowska; Carl Blomqvist; Stig E. Bojesen; Bernardo Bonanni; Ake Borg; Hiltrud Brauch; Hermann Brenner; Barbara Burwinkel; Saundra S. Buys; Trinidad Caldés; Maria A. Caligo; Daniele Campa; Brian D. Carter; Jose E. Castelao; Jenny Chang-Claude; Stephen J. Chanock; Wendy K. Chung; Kathleen B. M. Claes; Christine L. Clarke; GEMO Study Collaborators; EMBRACE Collaborators; J. Margriet Collée; Don M. Conroy; Kamila Czene; Mary B. Daly; Peter Devilee; Orland Diez; Yuan Chun Ding; Susan M. Domchek; Thilo Dörk; Isabel dos-Santos-Silva; Alison M. Dunning; Miriam Dwek; Diana M. Eccles; A. Heather Eliassen; Christoph Engel; Mikael Eriksson; D. Gareth Evans; Peter A. Fasching; Henrik Flyger; Florentia Fostira; Eitan Friedman; Lin Fritschi; Debra Frost; Manuela Gago-Dominguez; Susan M. Gapstur; Judy Garber; Vanesa Garcia-Barberan; Montserrat García-Closas; José A. García-Sáenz; Mia M. Gaudet; Simon A. Gayther; Andrea Gehrig; Vassilios Georgoulias; Graham G. Giles; Andrew K. Godwin; Mark S. Goldberg; David E. Goldgar; Anna González-Neira; Mark H. Greene; Pascal Guénel; Lothar Haeberle; Eric Hahnen; Christopher A. Haiman; Niclas Håkansson; Per Hall; Ute Hamann; Patricia A. Harrington; Steven N. Hart; Wei He; Frans B. L. Hogervorst; Antoinette Hollestelle; John L. Hopper; Darling J. Horcasitas; Peter J. Hulick; David J. Hunter; Evgeny N. Imyanitov; KConFab Investigators; HEBON Investigators; ABCTB Investigators; Agnes Jager; Anna Jakubowska; Paul A. James; Uffe Birk Jensen; Esther M. John; Michael E. Jones; Rudolf Kaaks; Pooja Middha Kapoor; Beth Y. Karlan; Renske Keeman; Elza Khusnutdinova; Johanna I. Kiiski; Yon-Dschun Ko; Veli-Matti Kosma; Peter Kraft; Allison W. Kurian; Yael Laitman; Diether Lambrechts; Loic Le Marchand; Jenny Lester; Fabienne Lesueur; Tricia Lindstrom; Adria Lopez-Fernández; Jennifer T. Loud; Craig Luccarini; Arto Mannermaa; Siranoush Manoukian; Sara Margolin; John W. M. Martens; Noura Mebirouk; Alfons Meindl; Austin Miller; Roger L. Milne; Marco Montagna; Katherine L. Nathanson; Susan L. Neuhausen; Heli Nevanlinna; Finn C. Nielsen; Katie M. O’Brien; Olufunmilayo I. Olopade; Janet E. Olson; Håkan Olsson; Ana Osorio; Laura Ottini; Tjoung-Won Park-Simon; Michael T. Parsons; Inge Sokilde Pedersen; Beth Peshkin; Paolo Peterlongo; Julian Peto; Paul D. P. Pharoah; Kelly-Anne Phillips; Eric C. Polley; Bruce Poppe; Nadege Presneau; Miquel Angel Pujana; Kevin Punie; Paolo Radice; Johanna Rantala; Muhammad U. Rashid; Gad Rennert; Hedy S. Rennert; Mark Robson; Atocha Romero; Maria Rossing; Emmanouil Saloustros; Dale P. Sandler; Regina Santella; Maren T. Scheuner; Marjanka K. Schmidt; Gunnar Schmidt; Christopher Scott; Priyanka Sharma; Penny Soucy; Melissa C. Southey; John J. Spinelli; Zoe Steinsnyder; Jennifer Stone; Dominique Stoppa-Lyonnet; Anthony Swerdlow; Rulla M. Tamimi; William J. Tapper; Jack A. Taylor; Mary Beth Terry; Alex Teulé; Darcy L. Thull; Marc Tischkowitz; Amanda E. Toland; Diana Torres; Alison H. Trainer; Thérèse Truong; Nadine Tung; Celine M. Vachon; Ana Vega; Joseph Vijai; Qin Wang; Barbara Wappenschmidt; Clarice R. Weinberg; Jeffrey N. Weitzel; Camilla Wendt; Alicja Wolk; Siddhartha Yadav; Xiaohong R. Yang; Drakoulis Yannoukakos; Wei Zheng; Argyrios Ziogas; Kristin K. Zorn; Sue K. Park; Mads Thomassen; Kenneth Offit; Rita K. Schmutzler; Fergus J. Couch; Jacques Simard; Georgia Chenevix-Trench; Douglas F. Easton; Nadine Andrieu; Antonis C. Antoniou
Source
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Breast cancer risk for BRCA1/BRCA2 mutation carriers varies depending on other genetic factors. Here, the authors perform a case-only genome-wide association study and highlight novel loci associated with breast cancer risk for BRCA1/BRCA2 mutation carriers.