학술논문
HLA in isolated REM sleep behavior disorder and Lewy body dementia
Document Type
article
Author
Eric Yu; Lynne Krohn; Jennifer A. Ruskey; Farnaz Asayesh; Dan Spiegelman; Zalak Shah; Ruth Chia; Isabelle Arnulf; Michele T. M. Hu; Jacques Y. Montplaisir; Jean‐François Gagnon; Alex Desautels; Yves Dauvilliers; Gian Luigi Gigli; Mariarosaria Valente; Francesco Janes; Andrea Bernardini; Birgit Högl; Ambra Stefani; Abubaker Ibrahim; Anna Heidbreder; Karel Sonka; Petr Dusek; David Kemlink; Wolfgang Oertel; Annette Janzen; Giuseppe Plazzi; Elena Antelmi; Michela Figorilli; Monica Puligheddu; Brit Mollenhauer; Claudia Trenkwalder; Friederike Sixel‐Döring; Valérie Cochen De Cock; Luigi Ferini‐Strambi; Femke Dijkstra; Mineke Viaene; Beatriz Abril; Bradley F. Boeve; Guy A. Rouleau; Ronald B. Postuma; The International LBD Genomics Consortium; Sonja W. Scholz; Ziv Gan‐Or
Source
Annals of Clinical and Translational Neurology, Vol 10, Iss 9, Pp 1682-1687 (2023)
Subject
Language
English
ISSN
2328-9503
Abstract
Abstract Synucleinopathies‐related disorders such as Lewy body dementia (LBD) and isolated/idiopathic REM sleep behavior disorder (iRBD) have been associated with neuroinflammation. In this study, we examined whether the human leukocyte antigen (HLA) locus plays a role in iRBD and LBD. In iRBD, HLA‐DRB1*11:01 was the only allele passing FDR correction (OR = 1.57, 95% CI = 1.27–1.93, p = 2.70e‐05). We also discovered associations between iRBD and HLA‐DRB1 70D (OR = 1.26, 95%CI = 1.12–1.41, p = 8.76e‐05), 70Q (OR = 0.81, 95%CI = 0.72–0.91, p = 3.65e‐04) and 71R (OR = 1.21, 95%CI = 1.08–1.35, p = 1.35e‐03). Position 71 (pomnibus = 0.00102) and 70 (pomnibus = 0.00125) were associated with iRBD. Our results suggest that the HLA locus may have different roles across synucleinopathies.