학술논문
Hypothyroidism does not lead to worse prognosis in COVID-19: findings from the Brazilian COVID-19 registry
Document Type
article
Author
Daniella Nunes Pereira; Leticia Ferreira Gontijo Silveira, MD, PhD; Milena Maria Moreira Guimarães; Carísi Anne Polanczyk; Aline Gabrielle Sousa Nunes; André Soares de Moura Costa; Barbara Lopes Farace; Christiane Corrêa Rodrigues Cimini; Cíntia Alcantara de Carvalho; Daniela Ponce; Eliane Würdig Roesch; Euler Roberto Fernandes Manenti; Fernanda Barbosa Lucas; Fernanda d'Athayde Rodrigues; Fernando Anschau; Fernando Graça Aranha; Frederico Bartolazzi; Giovanna Grunewald Vietta; Guilherme Fagundes Nascimento; Helena Duani; Heloisa Reniers Vianna; Henrique Cerqueira Guimarães; Jamille Hemétrio Salles Martins Costa; Joanna d'Arc Lyra Batista; Joice Coutinho de Alvarenga; José Miguel Chatkin; Júlia Drumond Parreiras de Morais; Juliana Machado-Rugolo; Karen Brasil Ruschel; Lílian Santos Pinheiro; Luanna Silva Monteiro Menezes; Luciana Siuves Ferreira Couto; Luciane Kopittke; Luís César de Castro; Luiz Antônio Nasi; Máderson Alvares de Souza Cabral; Maiara Anschau Floriani; Maíra Dias Souza; Marcelo Carneiro; Maria Aparecida Camargos Bicalho; Mariana Frizzo de Godoy; Matheus Carvalho Alves Nogueira; Milton Henriques Guimarães Júnior; Natália da Cunha Severino Sampaio; Neimy Ramos de Oliveira; Pedro Ledic Assaf; Renan Goulart Finger; Roberta Xavier Campos; Rochele Mosmann Menezes; Saionara Cristina Francisco; Samuel Penchel Alvarenga; Silvana Mangeon Mereilles Guimarães; Silvia Ferreira Araújo; Talita Fischer Oliveira; Thulio Henrique Oliveira Diniz; Yuri Carlotto Ramires; Evelin Paola de Almeida Cenci; Thainara Conceição de Oliveira; Alexandre Vargas Schwarzbold; Patricia Klarmann Ziegelmann; Roberta Pozza; Caroline Scherer Carvalho; Magda Carvalho Pires; Milena Soriano Marcolino
Source
International Journal of Infectious Diseases, Vol 116, Iss , Pp 319-327 (2022)
Subject
Language
English
ISSN
1201-9712
Abstract
Background: It is not clear whether previous thyroid diseases influence the course and outcomes of COVID-19. Methods: The study is a part of a multicentric cohort of patients with confirmed COVID-19 diagnosis from 37 hospitals. Matching for age, sex, number of comorbidities, and hospital was performed for the paired analysis. Results: Of 7,762 patients with COVID-19, 526 had previously diagnosed hypothyroidism and 526 were matched controls. The median age was 70 years, and 68.3% were females. The prevalence of comorbidities was similar, except for coronary and chronic kidney diseases that were higher in the hypothyroidism group (p=0.015 and p=0.001). D-dimer levels were lower in patients with hypothyroid (p=0.037). In-hospital management was similar, but hospital length-of-stay (p=0.029) and mechanical ventilation requirement (p=0.006) were lower for patients with hypothyroidism. There was a trend of lower in-hospital mortality in patients with hypothyroidism (22.1% vs 27.0%; p=0.062). Conclusion: Patients with hypothyroidism had a lower requirement of mechanical ventilation and showed a trend of lower in-hospital mortality. Therefore, hypothyroidism does not seem to be associated with a worse prognosis.