학술논문
Electric field causes volumetric changes in the human brain
Document Type
article
Author
Miklos Argyelan; Leif Oltedal; Zhi-De Deng; Benjamin Wade; Marom Bikson; Andrea Joanlanne; Sohag Sanghani; Hauke Bartsch; Marta Cano; Anders M Dale; Udo Dannlowski; Annemiek Dols; Verena Enneking; Randall Espinoza; Ute Kessler; Katherine L Narr; Ketil J Oedegaard; Mardien L Oudega; Ronny Redlich; Max L Stek; Akihiro Takamiya; Louise Emsell; Filip Bouckaert; Pascal Sienaert; Jesus Pujol; Indira Tendolkar; Philip van Eijndhoven; Georgios Petrides; Anil K Malhotra; Christopher Abbott
Source
eLife, Vol 8 (2019)
Subject
Language
English
ISSN
2050-084X
Abstract
Recent longitudinal neuroimaging studies in patients with electroconvulsive therapy (ECT) suggest local effects of electric stimulation (lateralized) occur in tandem with global seizure activity (generalized). We used electric field (EF) modeling in 151 ECT treated patients with depression to determine the regional relationships between EF, unbiased longitudinal volume change, and antidepressant response across 85 brain regions. The majority of regional volumes increased significantly, and volumetric changes correlated with regional electric field (t = 3.77, df = 83, r = 0.38, p=0.0003). After controlling for nuisance variables (age, treatment number, and study site), we identified two regions (left amygdala and left hippocampus) with a strong relationship between EF and volume change (FDR corrected p