학술논문
Astrovirus infects actively secreting goblet cells and alters the gut mucus barrier
Document Type
article
Author
Source
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Astroviruses are the leading cause of pediatric diarrhea, but which cells are the main targets in the gut remains unclear. Here, using an in vivo model of murine astrovirus, the authors show that the virus infects goblet cells and that this alters mucus production and increases mucus-associated bacterial communities in the gut.