학술논문
Coronopus didymus (L) sm. extracts per se and in combination with ferulic acid ameliorate allergic asthma through moderating aquaporins, inflammatory cytokines, and oxidative stress
Document Type
article
Author
Source
Journal of Functional Foods, Vol 118, Iss , Pp 106281- (2024)
Subject
Language
English
ISSN
1756-4646
Abstract
Asthma is a chronic heterogeneous illness that is clinically characterized by excessive mucous production and swelling of the airways due to hyperresponsiveness. The purpose of this work was to confirm the traditional usage of the food plant Coronopus didymus (CD) against ovalbumin-induced asthmatic symptoms, as well as chemical characterization of the extract by Gas Chromatography-Mass Spectrometry. After ovalbumin administration on days 1 and 14, oral therapy was carried out individually with CD aqueous ethanolic extract (CDAEE) and aqueous extract (CDAE) at 200, 400, and 800 mg/kg from day 15 to 26. In addition, the therapeutic effect of ferulic acid (FA) 100 mg/kg was investigated alone and in combination with CDAEE 800 mg/kg and CDAE 800 mg/kg. Dexamethasone served as a standard drug. Both extracts and combination groups profoundly (p