학술논문
Performance of the ROX index to predict intubation in immunocompromised patients receiving high-flow nasal cannula for acute respiratory failure
Document Type
article
Author
Virginie Lemiale; Guillaume Dumas; Alexandre Demoule; Frederic Pène; Achille Kouatchet; Magali Bisbal; Saad Nseir; Laurent Argaud; Loay Kontar; Kada Klouche; Francois Barbier; Amelie Seguin; Guillaume Louis; Jean-Michel Constantin; Julien Mayaux; Florent Wallet; Vincent Peigne; Christophe Girault; Johanna Oziel; Martine Nyunga; Nicolas Terzi; Lila Bouadma; Alexandre Lautrette; Naike Bige; Jean-Herle Raphalen; Laurent Papazian; Fabrice Bruneel; Christine Lebert; Dominique Benoit; Anne-Pascale Meert; Samir Jaber; Djamel Mokart; Michael Darmon; Elie Azoulay; The Groupe de Recherche en Reanimation Respiratoire du patient d’Onco-Hématologie (GRRR-OH)
Source
Annals of Intensive Care, Vol 11, Iss 1, Pp 1-9 (2021)
Subject
Language
English
ISSN
2110-5820
Abstract
Abstract Background Delayed intubation is associated with high mortality. There is a lack of objective criteria to decide the time of intubation. We assessed a recently described combined oxygenation index (ROX index) to predict intubation in immunocompromised patients. The study is a secondary analysis of randomized trials in immunocompromised patients, including all patients who received high-flow nasal cannula (HFNC). The first objective was to evaluate the accuracy of the ROX index to predict intubation for patients with acute respiratory failure. Results In the study, 302 patients received HFNC. Acute respiratory failure was mostly related to pneumonia (n = 150, 49.7%). Within 2 (1–3) days, 115 (38.1%) patients were intubated. The ICU mortality rate was 27.4% (n = 83). At 6 h, the ROX index was lower for patients who needed intubation compared with those who did not [4.79 (3.69–7.01) vs. 6.10 (4.48–8.68), p