학술논문
Association between SARS‐CoV‐2 viral kinetics and clinical score evolution in hospitalized patients
Document Type
article
Author
Nadège Néant; Guillaume Lingas; Alexandre Gaymard; Drifa Belhadi; Maya Hites; Thérèse Staub; Richard Greil; Jose‐Artur Paiva; Julien Poissy; Nathan Peiffer‐Smadja; Dominique Costagliola; Yazdan Yazdanpanah; Maude Bouscambert‐Duchamp; Amandine Gagneux‐Brunon; Florence Ader; France Mentré; Florent Wallet; Charles Burdet; Jérémie Guedj; the DisCoVeRy study group
Source
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 12, Pp 2027-2037 (2023)
Subject
Language
English
ISSN
2163-8306
Abstract
Abstract The role of antiviral treatment in coronavirus disease 2019 hospitalized patients is controversial. To address this question, we analyzed simultaneously nasopharyngeal viral load and the National Early Warning Score 2 (NEWS‐2) using an effect compartment model to relate viral dynamics and the evolution of clinical severity. The model is applied to 664 hospitalized patients included in the DisCoVeRy trial (NCT04315948; EudraCT 2020‐000936‐23) randomly assigned to either standard of care (SoC) or SoC + remdesivir. Then we use the model to simulate the impact of antiviral treatments on the time to clinical improvement, defined by a NEWS‐2 score lower than 3 (in patients with NEWS‐2