학술논문
Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma
Document Type
article
Author
Pratiti Bandopadhayay; Federica Piccioni; Ryan O’Rourke; Patricia Ho; Elizabeth M. Gonzalez; Graham Buchan; Kenin Qian; Gabrielle Gionet; Emily Girard; Margo Coxon; Matthew G. Rees; Lisa Brenan; Frank Dubois; Ofer Shapira; Noah F. Greenwald; Melanie Pages; Amanda Balboni Iniguez; Brenton R. Paolella; Alice Meng; Claire Sinai; Giovanni Roti; Neekesh V. Dharia; Amanda Creech; Benjamin Tanenbaum; Prasidda Khadka; Adam Tracy; Hong L. Tiv; Andrew L. Hong; Shannon Coy; Rumana Rashid; Jia-Ren Lin; Glenn S. Cowley; Fred C. Lam; Amy Goodale; Yenarae Lee; Kathleen Schoolcraft; Francisca Vazquez; William C. Hahn; Aviad Tsherniak; James E. Bradner; Michael B. Yaffe; Till Milde; Stefan M. Pfister; Jun Qi; Monica Schenone; Steven A. Carr; Keith L. Ligon; Mark W. Kieran; Sandro Santagata; James M. Olson; Prafulla C. Gokhale; Jacob D. Jaffe; David E. Root; Kimberly Stegmaier; Cory M. Johannessen; Rameen Beroukhim
Source
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
BET-bromodomain inhibitors could be used to treat medulloblastoma tumors with Myc amplifications. Here, the authors show that both the response and resistance to BET inhibitors in mice is mediated by bHLH/homeobox transcription factors.