학술논문
Case Report: Unmasked Inherited Dysfibrinogenemia After Everolimus Therapy
Document Type
article
Author
Source
Frontiers in Medicine, Vol 7 (2020)
Subject
Language
English
ISSN
2296-858X
Abstract
A previously hemostatically asymptomatic patient with common variable hypogammaglobulinemia was given everolimus to prevent growth of her liver. Within several months, the patient developed a severe bleeding disorder. The bleeding was due to fibrin polymerization defect that upon sequencing was shown to be dysfibrinogenemia Krakow III. Elimination of the mTor inhibitor ameliorated the clinical bleeding state.