학술논문
Prevalence and predictors of vitamin D deficiency in young African children
Document Type
article
Author
Reagan M. Mogire; Alireza Morovat; John Muthii Muriuki; Alexander J. Mentzer; Emily L. Webb; Wandia Kimita; Francis M. Ndungu; Alex W. Macharia; Clare L. Cutland; Sodiomon B. Sirima; Amidou Diarra; Alfred B. Tiono; Swaib A. Lule; Shabir A. Madhi; Manjinder S. Sandhu; Andrew M. Prentice; Philip Bejon; John M. Pettifor; Alison M. Elliott; Adebowale Adeyemo; Thomas N. Williams; Sarah H. Atkinson
Source
BMC Medicine, Vol 19, Iss 1, Pp 1-14 (2021)
Subject
Language
English
ISSN
1741-7015
Abstract
Abstract Background Children living in sub-Saharan Africa have a high burden of rickets and infectious diseases, conditions that are linked to vitamin D deficiency. However, data on the vitamin D status of young African children and its environmental and genetic predictors are limited. We aimed to examine the prevalence and predictors of vitamin D deficiency in young African children. Methods We measured 25-hydroxyvitamin D (25(OH)D) and typed the single nucleotide polymorphisms, rs4588 and rs7041, in the GC gene encoding the vitamin D binding protein (DBP) in 4509 children aged 0–8 years living in Kenya, Uganda, Burkina Faso, The Gambia and South Africa. We evaluated associations between vitamin D status and country, age, sex, season, anthropometric indices, inflammation, malaria and DBP haplotypes in regression analyses. Results Median age was 23.9 months (interquartile range [IQR] 12.3, 35.9). Prevalence of vitamin D deficiency using 25(OH)D cut-offs of