학술논문
Persistence of spike-specific immune responses in BNT162b2-vaccinated donors and generation of rapid ex-vivo T cells expansion protocol for adoptive immunotherapy: A pilot study
Document Type
article
Author
Sarra Mestiri; Maysaloun Merhi; Varghese P. Inchakalody; Nassiba Taib; Maria K. Smatti; Fareed Ahmad; Afsheen Raza; Fatma H. Ali; Shereena Hydrose; Queenie Fernandes; Abdul W. Ansari; Fairooz Sahir; Lobna Al-Zaidan; Munir Jalis; Mokhtar Ghoul; Niloofar Allahverdi; Mohammed U. Al Homsi; Shahab Uddin; Andrew Martin Jeremijenko; Mai Nimir; Laith J. Abu-Raddad; Fatma Ben Abid; Ahmed Zaqout; Sameer R. Alfheid; Hassan Mohamed Hassan Saqr; Ali S. Omrani; Ali Ait Hssain; Muna Al Maslamani; Hadi M. Yassine; Said Dermime
Source
Frontiers in Immunology, Vol 14 (2023)
Subject
Language
English
ISSN
1664-3224
Abstract
IntroductionThe BNT162b2 mRNA-based vaccine has shown high efficacy in preventing COVID-19 infection but there are limited data on the types and persistence of the humoral and T cell responses to such a vaccine.MethodsHere, we dissect the vaccine-induced humoral and cellular responses in a cohort of six healthy recipients of two doses of this vaccine.Results and discussionOverall, there was heterogeneity in the spike-specific humoral and cellular responses among vaccinated individuals. Interestingly, we demonstrated that anti-spike antibody levels detected by a novel simple automated assay (Jess) were strongly correlated (r=0.863, P