학술논문
Impact of renal impairment on outcomes after autologous stem cell transplantation in multiple myeloma: a multi-center, retrospective cohort study
Document Type
article
Author
Marlies Antlanger; Tobias Dust; Thomas Reiter; Alexandra Böhm; Wolfgang W. Lamm; Max Gornicec; Ella Willenbacher; David Nachbaur; Roman Weger; Werner Rabitsch; Susanne Rasoul-Rockenschaub; Nina Worel; Daniel Lechner; Hildegard Greinix; Felix Keil; Heinz Gisslinger; Hermine Agis; Maria-Theresa Krauth
Source
BMC Cancer, Vol 18, Iss 1, Pp 1-11 (2018)
Subject
Language
English
ISSN
1471-2407
Abstract
Abstract Background Renal impairment (RI) is a negative prognostic factor in Multiple Myeloma (MM) and affected patients are often excluded from autologous stem cell transplantation (ASCT). However, it remains unclear whether historically inferior outcome data still hold true. Methods From a total of 475 eligible MM patients who had undergone ASCT between 1998 and 2016, 374 were included in this multi-centric retrospective cohort study. Renal function was determined both at the time of MM diagnosis and ASCT by estimated glomerular filtration rate (eGFR according to the MDRD formula, RI defined as eGFR