학술논문
DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis
Document Type
article
Author
Lara Kular; Yun Liu; Sabrina Ruhrmann; Galina Zheleznyakova; Francesco Marabita; David Gomez-Cabrero; Tojo James; Ewoud Ewing; Magdalena Lindén; Bartosz Górnikiewicz; Shahin Aeinehband; Pernilla Stridh; Jenny Link; Till F. M. Andlauer; Christiane Gasperi; Heinz Wiendl; Frauke Zipp; Ralf Gold; Björn Tackenberg; Frank Weber; Bernhard Hemmer; Konstantin Strauch; Stefanie Heilmann-Heimbach; Rajesh Rawal; Ulf Schminke; Carsten O. Schmidt; Tim Kacprowski; Andre Franke; Matthias Laudes; Alexander T. Dilthey; Elisabeth G. Celius; Helle B. Søndergaard; Jesper Tegnér; Hanne F. Harbo; Annette B. Oturai; Sigurgeir Olafsson; Hannes P. Eggertsson; Bjarni V. Halldorsson; Haukur Hjaltason; Elias Olafsson; Ingileif Jonsdottir; Kari Stefansson; Tomas Olsson; Fredrik Piehl; Tomas J. Ekström; Ingrid Kockum; Andrew P. Feinberg; Maja Jagodic
Source
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
The human leukocyte antigen (HLA) haplotype DRB1*15:01 is the major risk factor for multiple sclerosis (MS). Here the authors find that DNA methylation at HLA-DRB1 gene mediates the effect of DRB1*15:01 and of a protective HLA variant on HLA-DRB1 expression and the risk of MS.