학술논문
Whole genome sequence analysis of blood lipid levels in >66,000 individuals
Document Type
article
Author
Margaret Sunitha Selvaraj; Xihao Li; Zilin Li; Akhil Pampana; David Y. Zhang; Joseph Park; Stella Aslibekyan; Joshua C. Bis; Jennifer A. Brody; Brian E. Cade; Lee-Ming Chuang; Ren-Hua Chung; Joanne E. Curran; Lisa de las Fuentes; Paul S. de Vries; Ravindranath Duggirala; Barry I. Freedman; Mariaelisa Graff; Xiuqing Guo; Nancy Heard-Costa; Bertha Hidalgo; Chii-Min Hwu; Marguerite R. Irvin; Tanika N. Kelly; Brian G. Kral; Leslie Lange; Xiaohui Li; Martin Lisa; Steven A. Lubitz; Ani W. Manichaikul; Preuss Michael; May E. Montasser; Alanna C. Morrison; Take Naseri; Jeffrey R. O’Connell; Nicholette D. Palmer; Patricia A. Peyser; Muagututia S. Reupena; Jennifer A. Smith; Xiao Sun; Kent D. Taylor; Russell P. Tracy; Michael Y. Tsai; Zhe Wang; Yuxuan Wang; Wei Bao; John T. Wilkins; Lisa R. Yanek; Wei Zhao; Donna K. Arnett; John Blangero; Eric Boerwinkle; Donald W. Bowden; Yii-Der Ida Chen; Adolfo Correa; L. Adrienne Cupples; Susan K. Dutcher; Patrick T. Ellinor; Myriam Fornage; Stacey Gabriel; Soren Germer; Richard Gibbs; Jiang He; Robert C. Kaplan; Sharon L. R. Kardia; Ryan Kim; Charles Kooperberg; Ruth J. F. Loos; Karine A Viaud-Martinez; Rasika A. Mathias; Stephen T. McGarvey; Braxton D. Mitchell; Deborah Nickerson; Kari E. North; Bruce M. Psaty; Susan Redline; Alexander P. Reiner; Ramachandran S. Vasan; Stephen S. Rich; Cristen Willer; Jerome I. Rotter; Daniel J. Rader; Xihong Lin; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Gina M. Peloso; Pradeep Natarajan
Source
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Although the common genetic variants contributing to blood lipid levels have been studied, the contribution of rare variants is less understood. Here, the authors perform a rare coding and noncoding variant association study of blood lipid levels using whole genome sequencing data.