학술논문
Extracellular LGALS3BP regulates neural progenitor position and relates to human cortical complexity
Document Type
article
Author
Christina Kyrousi; Adam C. O’Neill; Agnieska Brazovskaja; Zhisong He; Pavel Kielkowski; Laure Coquand; Rossella Di Giaimo; Pierpaolo D’ Andrea; Alexander Belka; Andrea Forero Echeverry; Davide Mei; Matteo Lenge; Cristiana Cruceanu; Isabel Y. Buchsbaum; Shahryar Khattak; Guimiot Fabien; Elisabeth Binder; Frances Elmslie; Renzo Guerrini; Alexandre D. Baffet; Stephan A. Sieber; Barbara Treutlein; Stephen P. Robertson; Silvia Cappello
Source
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Basal progenitors are enriched in gyrencephalic species like humans contributing to neuronal expansion. Here the authors show that LGALS3BP de novo variants are related to reduced cortical complexity and area in humans and that LGALS3BP regulates neural progenitor position in organoids, human fetal tissue and mice.