학술논문
Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer
Document Type
article
Author
Alex H. Wagner; Siddhartha Devarakonda; Zachary L. Skidmore; Kilannin Krysiak; Avinash Ramu; Lee Trani; Jason Kunisaki; Ashiq Masood; Saiama N. Waqar; Nicholas C. Spies; Daniel Morgensztern; Jason Waligorski; Jennifer Ponce; Robert S. Fulton; Leonard B. Maggi; Jason D. Weber; Mark A. Watson; Christopher J. O’Conor; Jon H. Ritter; Rachelle R. Olsen; Haixia Cheng; Anandaroop Mukhopadhyay; Ismail Can; Melissa H. Cessna; Trudy G. Oliver; Elaine R. Mardis; Richard K. Wilson; Malachi Griffith; Obi L. Griffith; Ramaswamy Govindan
Source
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
Small cell lung cancer (SCLC) patients frequently relapse and become resistant to chemotherapy. Here, the authors analyse the genomic and transcriptomic landscape of primary and relapsed SCLC patients as well as in vitro models, and discover that activation of WNT signalling can drive chemotherapy resistance.