학술논문
IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization
Document Type
article
Author
Moritz F. Eissmann; Christine Dijkstra; Andrew Jarnicki; Toby Phesse; Jamina Brunnberg; Ashleigh R. Poh; Nima Etemadi; Evelyn Tsantikos; Stefan Thiem; Nicholas D. Huntington; Margaret L. Hibbs; Alex Boussioutas; Michele A. Grimbaldeston; Michael Buchert; Robert J. J. O’Donoghue; Frederick Masson; Matthias Ernst
Source
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
Mast cells within the tumor microenvironment have controversial roles. Here, the authors show, using genetic mouse models, that in gastric cancer, mast cells at the periphery of the tumors are activated via cancer cell produced-IL33 and promote tumorigenesis by recruiting macrophages within the tumors.