학술논문
Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation
Document Type
article
Author
Source
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Subject
Language
English
ISSN
2041-1723
Abstract
Targeting the ubiquitin proteasome system to modulate protein homeostasis using small molecules has promising therapeutic potential. Here the authors describe Homo-PROTACS: small molecules that can induce the homo-dimerization of E3 ubiquitin ligases and cause their proteasome-dependent degradation.