학술논문
Pertactin-Deficient Bordetella pertussis with Unusual Mechanism of Pertactin Disruption, Spain, 1986–2018
Document Type
article
Author
Alba Mir-Cros; Albert Moreno-Mingorance; M. Teresa Martín-Gómez; Raquel Abad; Iván Bloise; Magda Campins; Alejandro González-Praetorius; M. Nieves Gutiérrez; Héctor Martín-González; Carmen Muñoz-Almagro; M. Ángeles Orellana; Manuela de Pablos; Josep Roca-Grande; Carlos Rodrigo; M. Elena Rodríguez; Sonia Uriona; M. José Vidal; Tomàs Pumarola; M. Nieves Larrosa; Juan José González-López
Source
Emerging Infectious Diseases, Vol 28, Iss 5, Pp 967-976 (2022)
Subject
Language
English
ISSN
1080-6040
1080-6059
1080-6059
Abstract
Bordetella pertussis not expressing pertactin has increased in countries using acellular pertussis vaccines (ACV). The deficiency is mostly caused by pertactin gene disruption by IS481. To assess the effect of the transition from whole-cell vaccine to ACV on the emergence of B. pertussis not expressing pertactin in Spain, we studied 342 isolates collected during 1986–2018. We identified 93 pertactin-deficient isolates. All were detected after introduction of ACV and represented 38% of isolates collected during the ACV period; 58.1% belonged to a genetic cluster of isolates carrying the unusual prn::del(–292, 1340) mutation. Pertactin inactivation by IS481 insertion was identified in 23.7% of pertactin-deficient isolates, arising independently multiple times and in different phylogenetic branches. Our findings support the emergence and dissemination of a cluster of B. pertussis with an infrequent mechanism of pertactin disruption in Spain, probably resulting from introduction of ACV.