학술논문
Differences between familial and sporadic dilated cardiomyopathy: ESC EORP Cardiomyopathy & Myocarditis registry
Document Type
article
Author
Folkert W. Asselbergs; Arjan Sammani; Perry Elliott; Juan R. Gimeno; Luigi Tavazzi; Michael Tendera; Juan Pablo Kaski; Aldo P. Maggioni; Pawel P. Rubis; Ruxandra Jurcut; Tiina Heliö; Leonardo Calò; Gianfranco Sinagra; Marija Zdravkovic; Iacopo Olivotto; Aušra Kavoliūnienė; Cécile Laroche; Alida L.P. Caforio; Philippe Charron; Cardiomyopathy & Myocarditis Registry Investigators Group
Source
ESC Heart Failure, Vol 8, Iss 1, Pp 95-105 (2021)
Subject
Language
English
ISSN
2055-5822
Abstract
Abstract Aims Dilated cardiomyopathy (DCM) is a complex disease where genetics interplay with extrinsic factors. This study aims to compare the phenotype, management, and outcome of familial DCM (FDCM) and non‐familial (sporadic) DCM (SDCM) across Europe. Methods and results Patients with DCM that were enrolled in the prospective ESC EORP Cardiomyopathy & Myocarditis Registry were included. Baseline characteristics, genetic testing, genetic yield, and outcome were analysed comparing FDCM and SDCM; 1260 adult patients were studied (238 FDCM, 707 SDCM, and 315 not disclosed). Patients with FDCM were younger (P