학술논문
Development and Evaluation of the Magnetic Properties of a New Manganese (II) Complex: A Potential MRI Contrast Agent
Document Type
article
Author
Giovanni Reale; Francesca Calderoni; Teresa Ghirardi; Francesca Porto; Federica Illuminati; Lorenza Marvelli; Petra Martini; Licia Uccelli; Eugenia Tonini; Lucia Del Bianco; Federico Spizzo; Martina Capozza; Emiliano Cazzola; Aldo Carnevale; Melchiore Giganti; Alessandro Turra; Juan Esposito; Alessandra Boschi
Source
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3461 (2023)
Subject
Language
English
ISSN
1422-0067
1661-6596
1661-6596
Abstract
Magnetic resonance imaging (MRI) is a non-invasive powerful modern clinical technique that is extensively used for the high-resolution imaging of soft tissues. To obtain high-definition pictures of tissues or of the whole organism this technique is enhanced by the use of contrast agents. Gadolinium-based contrast agents have an excellent safety profile. However, over the last two decades, some specific concerns have surfaced. Mn(II) has different favorable physicochemical characteristics and a good toxicity profile, which makes it a good alternative to the Gd(III)-based MRI contrast agents currently used in clinics. Mn(II)-disubstituted symmetrical complexes containing dithiocarbamates ligands were prepared under a nitrogen atmosphere. The magnetic measurements on Mn complexes were carried out with MRI phantom measurements at 1.5 T with a clinical magnetic resonance. Relaxivity values, contrast, and stability were evaluated by appropriate sequences. Studies conducted to evaluate the properties of paramagnetic imaging in water using a clinical magnetic resonance showed that the contrast, produced by the complex [Mn(II)(L’)2] × 2H2O (L’ = 1.4-dioxa-8-azaspiro[4.5]decane-8-carbodithioate), is comparable to that produced by gadolinium complexes currently used in medicine as a paramagnetic contrast agent.