학술논문
A systems genomics approach to uncover patient-specific pathogenic pathways and proteins in ulcerative colitis
Document Type
article
Author
Johanne Brooks-Warburton; Dezso Modos; Padhmanand Sudhakar; Matthew Madgwick; John P. Thomas; Balazs Bohar; David Fazekas; Azedine Zoufir; Orsolya Kapuy; Mate Szalay-Beko; Bram Verstockt; Lindsay J. Hall; Alastair Watson; Mark Tremelling; Miles Parkes; Severine Vermeire; Andreas Bender; Simon R. Carding; Tamas Korcsmaros
Source
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Single Nucleotide Polymorphisms (SNPs) affect cellular regulatory networks, and SNP co-occurrences contribute to disease pathogenesis in ulcerative colitis (UC). Here the authors introduce iSNP, a precision medicine pipeline that combines genomics and network biology approaches to uncover patient specific pathways affected in complex diseases.