학술논문
Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes
Document Type
article
Author
Parsa Akbari; Olukayode A. Sosina; Jonas Bovijn; Karl Landheer; Jonas B. Nielsen; Minhee Kim; Senem Aykul; Tanima De; Mary E. Haas; George Hindy; Nan Lin; Ian R. Dinsmore; Jonathan Z. Luo; Stefanie Hectors; Benjamin Geraghty; Mary Germino; Lampros Panagis; Prodromos Parasoglou; Johnathon R. Walls; Gabor Halasz; Gurinder S. Atwal; Regeneron Genetics Center; DiscovEHR Collaboration; Marcus Jones; Michelle G. LeBlanc; Christopher D. Still; David J. Carey; Alice Giontella; Marju Orho-Melander; Jaime Berumen; Pablo Kuri-Morales; Jesus Alegre-Díaz; Jason M. Torres; Jonathan R. Emberson; Rory Collins; Daniel J. Rader; Brian Zambrowicz; Andrew J. Murphy; Suganthi Balasubramanian; John D. Overton; Jeffrey G. Reid; Alan R. Shuldiner; Michael Cantor; Goncalo R. Abecasis; Manuel A. R. Ferreira; Mark W. Sleeman; Viktoria Gusarova; Judith Altarejos; Charles Harris; Aris N. Economides; Vincent Idone; Katia Karalis; Giusy Della Gatta; Tooraj Mirshahi; George D. Yancopoulos; Olle Melander; Jonathan Marchini; Roberto Tapia-Conyer; Adam E. Locke; Aris Baras; Niek Verweij; Luca A. Lotta
Source
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Fat distribution is associated with cardiometabolic disease, although it has been less well studied than overall obesity. In a multiancestry exome-sequencing study, the authors identified predicted loss-of-function mutations in INHBE associated with favorable fat distribution and protection from type 2 diabetes.