학술논문
Protein kinase Cι: A versatile oncogene in the lung
Document Type
article
Source
Molecular & Cellular Oncology, Vol 5, Iss 5 (2018)
Subject
Language
English
ISSN
2372-3556
23723556
23723556
Abstract
We have recently demonstrated that protein kinase Cι (PKCι) promotes a stem-like, tumor-initiating cell phenotype in KRAS-driven lung adenocarcinoma by activating a novel ELF3-NOTCH3 signaling axis. Combined PKCι and NOTCH inhibition was identified as a novel strategy for the treatment of KRAS-driven lung adenocarcinoma.