학술논문
Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age
Document Type
article
Author
Simon Kebede Merid; Alexei Novoloaca; Gemma C. Sharp; Leanne K. Küpers; Alvin T. Kho; Ritu Roy; Lu Gao; Isabella Annesi-Maesano; Pooja Jain; Michelle Plusquin; Manolis Kogevinas; Catherine Allard; Florianne O. Vehmeijer; Nabila Kazmi; Lucas A. Salas; Faisal I. Rezwan; Hongmei Zhang; Sylvain Sebert; Darina Czamara; Sheryl L. Rifas-Shiman; Phillip E. Melton; Debbie A. Lawlor; Göran Pershagen; Carrie V. Breton; Karen Huen; Nour Baiz; Luigi Gagliardi; Tim S. Nawrot; Eva Corpeleijn; Patrice Perron; Liesbeth Duijts; Ellen Aagaard Nohr; Mariona Bustamante; Susan L. Ewart; Wilfried Karmaus; Shanshan Zhao; Christian M. Page; Zdenko Herceg; Marjo-Riitta Jarvelin; Jari Lahti; Andrea A. Baccarelli; Denise Anderson; Priyadarshini Kachroo; Caroline L. Relton; Anna Bergström; Brenda Eskenazi; Munawar Hussain Soomro; Paolo Vineis; Harold Snieder; Luigi Bouchard; Vincent W. Jaddoe; Thorkild I. A. Sørensen; Martine Vrijheid; S. Hasan Arshad; John W. Holloway; Siri E. Håberg; Per Magnus; Terence Dwyer; Elisabeth B. Binder; Dawn L. DeMeo; Judith M. Vonk; John Newnham; Kelan G. Tantisira; Inger Kull; Joseph L. Wiemels; Barbara Heude; Jordi Sunyer; Wenche Nystad; Monica C. Munthe-Kaas; Katri Räikkönen; Emily Oken; Rae-Chi Huang; Scott T. Weiss; Josep Maria Antó; Jean Bousquet; Ashish Kumar; Cilla Söderhäll; Catarina Almqvist; Andres Cardenas; Olena Gruzieva; Cheng-Jian Xu; Sarah E. Reese; Juha Kere; Petter Brodin; Olivia Solomon; Matthias Wielscher; Nina Holland; Akram Ghantous; Marie-France Hivert; Janine F. Felix; Gerard H. Koppelman; Stephanie J. London; Erik Melén
Source
Genome Medicine, Vol 12, Iss 1, Pp 1-17 (2020)
Subject
Language
English
ISSN
1756-994X
Abstract
Abstract Background Preterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated associations between gestational age and blood DNA methylation in children. Methods We performed meta-analysis of Illumina’s HumanMethylation450-array associations between gestational age and cord blood DNA methylation in 3648 newborns from 17 cohorts without common pregnancy complications, induced delivery or caesarean section. We also explored associations of gestational age with DNA methylation measured at 4–18 years in additional pediatric cohorts. Follow-up analyses of DNA methylation and gene expression correlations were performed in cord blood. DNA methylation profiles were also explored in tissues relevant for gestational age health effects: fetal brain and lung. Results We identified 8899 CpGs in cord blood that were associated with gestational age (range 27–42 weeks), at Bonferroni significance, P