학술논문
Significance of body temperature in elderly patients with sepsis
Document Type
article
Author
Takashi Shimazui; Taka-aki Nakada; Keith R. Walley; Taku Oshima; Toshikazu Abe; Hiroshi Ogura; Atsushi Shiraishi; Shigeki Kushimoto; Daizoh Saitoh; Seitaro Fujishima; Toshihiko Mayumi; Yasukazu Shiino; Takehiko Tarui; Toru Hifumi; Yasuhiro Otomo; Kohji Okamoto; Yutaka Umemura; Joji Kotani; Yuichiro Sakamoto; Junichi Sasaki; Shin-ichiro Shiraishi; Kiyotsugu Takuma; Ryosuke Tsuruta; Akiyoshi Hagiwara; Kazuma Yamakawa; Tomohiko Masuno; Naoshi Takeyama; Norio Yamashita; Hiroto Ikeda; Masashi Ueyama; Satoshi Fujimi; Satoshi Gando; on behalf of the JAAM FORECAST Group
Source
Critical Care, Vol 24, Iss 1, Pp 1-9 (2020)
Subject
Language
English
ISSN
1364-8535
Abstract
Abstract Background Elderly patients have a blunted host response, which may influence vital signs and clinical outcomes of sepsis. This study was aimed to investigate whether the associations between the vital signs and mortality are different in elderly and non-elderly patients with sepsis. Methods This was a retrospective observational study. A Japanese multicenter sepsis cohort (FORECAST, n = 1148) was used for the discovery analyses. Significant discovery results were tested for replication using two validation cohorts of sepsis (JAAMSR, Japan, n = 624; SPH, Canada, n = 1004). Patients were categorized into elderly and non-elderly groups (age ≥ 75 or