학술논문
The structural basis of promiscuity in small multidrug resistance transporters
Document Type
article
Author
Source
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Gdx-Clo is a bacterial transporter from the small multidrug resistance (SMR) family. Here, the authors use solid supported membrane electrophysiology to characterize Gdx-Clo functionally and report crystal structures of Gdx-Clo which confirm the dual topology architecture and offer insight into substrate binding and transport mechanism.