학술논문
Malfunctioning CD106-positive, short-term hematopoietic stem cells trigger diabetic neuropathy in mice by cell fusion
Document Type
article
Author
Source
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Subject
Language
English
ISSN
2399-3642
Abstract
Katagi et al. show that abnormal bone marrow-derived cells originated from hematopoietic stem cells (CD106-positive short-term HSCs) aberrantly fuse with neurons to develop diabetic neuropathy. This study suggests that the pathological abnormality is memorized in the bone marrow and that it cannot be erased by conventional therapy.