학술논문
Pubertal timing, sex hormone levels, and associations between early life adversity and accelerated development amongst 11-year-old children of parents with schizophrenia or bipolar disorder and controls: The Danish high risk and Resilience study via 11
Document Type
article
Author
Mette Falkenberg Krantz; Hanne Frederiksen; Carsten Hjorthøj; Anne Søndergaard; Julie Marie Brandt; Sinnika Birkehøj Rohd; Lotte Veddum; Nanna Lawaetz Steffensen; Christina Bruun Knudsen; Anna Krogh Andreasen; Nicoline Hemager; Birgitte Klee Burton; Maja Gregersen; Aja Neergaard Greve; Jessica Ohland; Vibeke Bliksted; Ole Mors; Anne A.E. Thorup; Anders Juul; Merete Nordentoft
Source
Comprehensive Psychoneuroendocrinology, Vol 16, Iss , Pp 100204- (2023)
Subject
Language
English
ISSN
2666-4976
Abstract
Background: Children of parents with severe mental illness have several known risk factors for altered pubertal timing. Pubertal timing is important for children’s physical and emotional development. We aimed to examine pubertal timing and associations between pubertal timing, early life adversity and child problem behavior including psychiatric diagnoses among children of parents with schizophrenia or bipolar disorder and controls. Methods: Self-reported Tanner stage (mean age 11.9, range 10.87–12.67), sex hormone levels, home environment, placement out of home, and problem behavior including psychiatric diagnoses of children at familial high-risk (FHR) of schizophrenia (FHR-SZ), bipolar disorder (FHR-BP) and population-based controls (PBC) were assessed. Results: A total of 465 children participated in the study (Tanner assessment N = 417, sex hormones N = 293). Assessed with self-reported Tanner, no difference in pubertal timing was found between groups (p = 0.09). Hormone levels did not differ between groups except for inhibin B (mean (SD) = 55.86 (29.13) pg/mL for FHR-SZ girls vs 84.98 (47.98) pg/mL) for PBC girls (p