학술논문
Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals
Document Type
article
Author
Kira J. Stanzick; Yong Li; Pascal Schlosser; Mathias Gorski; Matthias Wuttke; Laurent F. Thomas; Humaira Rasheed; Bryce X. Rowan; Sarah E. Graham; Brett R. Vanderweff; Snehal B. Patil; VA Million Veteran Program; Cassiane Robinson-Cohen; John M. Gaziano; Christopher J. O’Donnell; Cristen J. Willer; Stein Hallan; Bjørn Olav Åsvold; Andre Gessner; Adriana M. Hung; Cristian Pattaro; Anna Köttgen; Klaus J. Stark; Iris M. Heid; Thomas W. Winkler
Source
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Identifying causal variants and genes in genome-wide association studies remains a challenge, an issue that is ameliorated with larger sample sizes. Here the authors meta-analyze kidney function genome-wide association studies to identify new loci and fine-map loci to home in on variants and genes involved in kidney function.