학술논문
Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program
Document Type
article
Author
Jacklyn N. Hellwege; Digna R. Velez Edwards; Ayush Giri; Chengxiang Qiu; Jihwan Park; Eric S. Torstenson; Jacob M. Keaton; O. D. Wilson; Cassianne Robinson-Cohen; Cecilia P. Chung; Christianne L. Roumie; Derek Klarin; Scott M. Damrauer; Scott L. DuVall; Edward Siew; Elvis A. Akwo; Matthias Wuttke; Mathias Gorski; Man Li; Yong Li; J. Michael Gaziano; Peter W. F. Wilson; Philip S. Tsao; Christopher J. O’Donnell; Csaba P. Kovesdy; Cristian Pattaro; Anna Köttgen; Katalin Susztak; Todd L. Edwards; Adriana M. Hung
Source
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
Persistently low levels of estimated glomerular filtration rate (eGFR) are a biomarker of chronic kidney disease. Here, the authors reinterpret the genetic architecture of kidney function across ancestries, to identify not only genes, but the tissue and anatomical contexts of renal homeostasis.