학술논문

Acute seizure therapies in people with epilepsy: Fact or fiction? A U.S. Perspective
Document Type
article
Source
Epilepsy & Behavior Reports, Vol 23, Iss , Pp 100612- (2023)
Subject
Acute repetitive seizures
Benzodiazepines
Rescue therapy
Seizure cluster
Therapeutic misconception
Neurology. Diseases of the nervous system
RC346-429
Neurophysiology and neuropsychology
QP351-495
Language
English
ISSN
2589-9864
Abstract
Patients with epilepsy (PWE) may experience seizure emergencies including acute repetitive seizures despite chronic treatment with daily antiseizure medications. Seizures may adversely impact routine daily activities and/or healthcare utilization and may impair the quality of life of patients with epilepsy and their caregivers. Seizures often occur at home, school, or work in a community setting. Appropriate treatment that is readily accessible for patients with seizure urgencies and emergencies is essential outside the hospital setting. When determining the best acute antiseizure therapy for PWE, clinicians need to consider all of the available rescue medications and their routes of administration including the safety and efficacy profiles. Benzodiazepines are a standard of care as a rescue therapy, yet there are several misconceptions about their use and safety. Reevaluating potential misconceptions and formulating best practices are necessary to maximize usage for each available option of acute therapy. We examine common beliefs associated with traditional use of acute seizure therapies to refute or support them based on the current level of evidence in the published literature.