학술논문
Neurological diagnoses in hospitalized COVID-19 patients associated with adverse outcomes: A multinational cohort study.
Document Type
article
Author
Meghan R Hutch; Jiyeon Son; Trang T Le; Chuan Hong; Xuan Wang; Zahra Shakeri Hossein Abad; Michele Morris; Alba Gutiérrez-Sacristán; Jeffrey G Klann; Anastasia Spiridou; Ashley Batugo; Riccardo Bellazzi; Vincent Benoit; Clara-Lea Bonzel; William A Bryant; Lorenzo Chiudinelli; Kelly Cho; Priyam Das; Tomás González González; David A Hanauer; Darren W Henderson; Yuk-Lam Ho; Ne Hooi Will Loh; Adeline Makoudjou; Simran Makwana; Alberto Malovini; Bertrand Moal; Danielle L Mowery; Antoine Neuraz; Malarkodi Jebathilagam Samayamuthu; Fernando J Sanz Vidorreta; Emily R Schriver; Petra Schubert; Jeffery Talbert; Amelia L M Tan; Byorn W L Tan; Bryce W Q Tan; Valentina Tibollo; Patric Tippman; Guillaume Verdy; William Yuan; Paul Avillach; Nils Gehlenborg; Gilbert S Omenn; Consortium for Clinical Characterization of COVID-19 by EHR (4CE); Shyam Visweswaran; Tianxi Cai; Yuan Luo; Zongqi Xia
Source
PLOS Digital Health, Vol 3, Iss 4, p e0000484 (2024)
Subject
Language
English
ISSN
2767-3170
Abstract
Few studies examining the patient outcomes of concurrent neurological manifestations during acute COVID-19 leveraged multinational cohorts of adults and children or distinguished between central and peripheral nervous system (CNS vs. PNS) involvement. Using a federated multinational network in which local clinicians and informatics experts curated the electronic health records data, we evaluated the risk of prolonged hospitalization and mortality in hospitalized COVID-19 patients from 21 healthcare systems across 7 countries. For adults, we used a federated learning approach whereby we ran Cox proportional hazard models locally at each healthcare system and performed a meta-analysis on the aggregated results to estimate the overall risk of adverse outcomes across our geographically diverse populations. For children, we reported descriptive statistics separately due to their low frequency of neurological involvement and poor outcomes. Among the 106,229 hospitalized COVID-19 patients (104,031 patients ≥18 years; 2,198 patients