학술논문
Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state
Document Type
article
Author
Peter G. Miller; Murugappan Sathappa; Jamie A. Moroco; Wei Jiang; Yue Qian; Sumaiya Iqbal; Qi Guo; Andrew O. Giacomelli; Subrata Shaw; Camille Vernier; Besnik Bajrami; Xiaoping Yang; Cerise Raffier; Adam S. Sperling; Christopher J. Gibson; Josephine Kahn; Cyrus Jin; Matthew Ranaghan; Alisha Caliman; Merissa Brousseau; Eric S. Fischer; Robert Lintner; Federica Piccioni; Arthur J. Campbell; David E. Root; Colin W. Garvie; Benjamin L. Ebert
Source
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
In this work, the authors report a sophisticated combination of genetic, biophysical, and biochemical analyses to identifies the cycling conformational states of PPM1D. The findings reveal how an allosteric inhibitor locks the protein into a conformationally inactive state, and explain the distribution of PPM1D activating mutations in cancer.