학술논문
Widespread intronic polyadenylation diversifies immune cell transcriptomes
Document Type
article
Author
Source
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
Recognition of intronic polyadenylation (IpA) signals can lead to expression of truncated proteins lacking C terminal domains. Analysis of 3ʹ -seq and RNA-seq shows that IpA is widespread in circulating immune cells, while multiple myeloma cells show loss of IpA isoforms that are normally expressed in plasma cells, impacting key genes in the disease.