학술논문
Functional dissection of inherited non-coding variation influencing multiple myeloma risk
Document Type
article
Author
Ram Ajore; Abhishek Niroula; Maroulio Pertesi; Caterina Cafaro; Malte Thodberg; Molly Went; Erik L. Bao; Laura Duran-Lozano; Aitzkoa Lopez de Lapuente Portilla; Thorunn Olafsdottir; Nerea Ugidos-Damboriena; Olafur Magnusson; Mehmet Samur; Caleb A. Lareau; Gisli H. Halldorsson; Gudmar Thorleifsson; Gudmundur L. Norddahl; Kristbjorg Gunnarsdottir; Asta Försti; Hartmut Goldschmidt; Kari Hemminki; Frits van Rhee; Scott Kimber; Adam S. Sperling; Martin Kaiser; Kenneth Anderson; Ingileif Jonsdottir; Nikhil Munshi; Thorunn Rafnar; Anders Waage; Niels Weinhold; Unnur Thorsteinsdottir; Vijay G. Sankaran; Kari Stefansson; Richard Houlston; Björn Nilsson
Source
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
The causality and functional roles of disease-associated variants revealed by genome-wide association studies (GWAS) are mostly unexplored. Here the authors identify putative causal variants in multiple myeloma and find their association with gene expression and chromatin accessibility.