학술논문
Phase 2 of extracellular RNA communication consortium charts next-generation approaches for extracellular RNA research
Document Type
article
Author
Bogdan Mateescu; Jennifer C. Jones; Roger P. Alexander; Eric Alsop; Ji Yeong An; Mohammad Asghari; Alex Boomgarden; Laura Bouchareychas; Alfonso Cayota; Hsueh-Chia Chang; Al Charest; Daniel T. Chiu; Robert J. Coffey; Saumya Das; Peter De Hoff; Andrew deMello; Crislyn D’Souza-Schorey; David Elashoff; Kiarash R. Eliato; Jeffrey L. Franklin; David J. Galas; Mark B. Gerstein; Ionita H. Ghiran; David B. Go; Stephen Gould; Tristan R. Grogan; James N. Higginbotham; Florian Hladik; Tony Jun Huang; Xiaoye Huo; Elizabeth Hutchins; Dennis K. Jeppesen; Tijana Jovanovic-Talisman; Betty Y.S. Kim; Sung Kim; Kyoung-Mee Kim; Yong Kim; Robert R. Kitchen; Vaughan Knouse; Emily L. LaPlante; Carlito B. Lebrilla; L. James Lee; Kathleen M. Lennon; Guoping Li; Feng Li; Tieyi Li; Tao Liu; Zirui Liu; Adam L. Maddox; Kyle McCarthy; Bessie Meechoovet; Nalin Maniya; Yingchao Meng; Aleksandar Milosavljevic; Byoung-Hoon Min; Amber Morey; Martin Ng; John Nolan; Getulio P. De Oliveira Junior; Michael E. Paulaitis; Tuan Anh Phu; Robert L. Raffai; Eduardo Reátegui; Matthew E. Roth; David A. Routenberg; Joel Rozowsky; Joseph Rufo; Satyajyoti Senapati; Sigal Shachar; Himani Sharma; Anil K. Sood; Stavros Stavrakis; Alessandra Stürchler; Muneesh Tewari; Juan P. Tosar; Alexander K. Tucker-Schwartz; Andrey Turchinovich; Nedyalka Valkov; Kendall Van Keuren-Jensen; Kasey C. Vickers; Lucia Vojtech; Wyatt N. Vreeland; Ceming Wang; Kai Wang; ZeYu Wang; Joshua A. Welsh; Kenneth W. Witwer; David T.W. Wong; Jianping Xia; Ya-Hong Xie; Kaichun Yang; Mikołaj P. Zaborowski; Chenguang Zhang; Qin Zhang; Angela M. Zivkovic; Louise C. Laurent
Source
iScience, Vol 25, Iss 8, Pp 104653- (2022)
Subject
Language
English
ISSN
2589-0042
Abstract
Summary: The extracellular RNA communication consortium (ERCC) is an NIH-funded program aiming to promote the development of new technologies, resources, and knowledge about exRNAs and their carriers. After Phase 1 (2013–2018), Phase 2 of the program (ERCC2, 2019–2023) aims to fill critical gaps in knowledge and technology to enable rigorous and reproducible methods for separation and characterization of both bulk populations of exRNA carriers and single EVs. ERCC2 investigators are also developing new bioinformatic pipelines to promote data integration through the exRNA atlas database. ERCC2 has established several Working Groups (Resource Sharing, Reagent Development, Data Analysis and Coordination, Technology Development, nomenclature, and Scientific Outreach) to promote collaboration between ERCC2 members and the broader scientific community. We expect that ERCC2’s current and future achievements will significantly improve our understanding of exRNA biology and the development of accurate and efficient exRNA-based diagnostic, prognostic, and theranostic biomarker assays.