학술논문
Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits
Document Type
article
Author
Arthur Gilly; Daniel Suveges; Karoline Kuchenbaecker; Martin Pollard; Lorraine Southam; Konstantinos Hatzikotoulas; Aliki-Eleni Farmaki; Thea Bjornland; Ryan Waples; Emil V. R. Appel; Elisabetta Casalone; Giorgio Melloni; Britt Kilian; Nigel W. Rayner; Ioanna Ntalla; Kousik Kundu; Klaudia Walter; John Danesh; Adam Butterworth; Inês Barroso; Emmanouil Tsafantakis; George Dedoussis; Ida Moltke; Eleftheria Zeggini
Source
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
Rare genetic variants can contribute to complex traits but this contribution is not well understood. Here, the authors analyse deep whole genome sequencing data across 1457 individuals from an isolated Greek population and find association of rare variant burdens with cardiometabolic traits.