학술논문
Antigen glycosylation regulates efficacy of CAR T cells targeting CD19
Document Type
article
Author
Amanda Heard; Jack H. Landmann; Ava R. Hansen; Alkmini Papadopolou; Yu-Sung Hsu; Mehmet Emrah Selli; John M. Warrington; John Lattin; Jufang Chang; Helen Ha; Martina Haug-Kroeper; Balraj Doray; Saar Gill; Marco Ruella; Katharina E. Hayer; Matthew D. Weitzman; Abby M. Green; Regina Fluhrer; Nathan Singh
Source
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Loss of surface CD19 expression by leukemic cells leads to resistance and relapse to CD19-targeted CAR-T therapies. Here the authors show that loss of SPPL3 in malignant B cells results in hyperglycosylation of CD19.