학술논문
Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease
Document Type
article
Author
Edmund J. Keliher; Yu-Xiang Ye; Gregory R. Wojtkiewicz; Aaron D. Aguirre; Benoit Tricot; Max L. Senders; Hannah Groenen; Francois Fay; Carlos Perez-Medina; Claudia Calcagno; Giuseppe Carlucci; Thomas Reiner; Yuan Sun; Gabriel Courties; Yoshiko Iwamoto; Hye-Yeong Kim; Cuihua Wang; John W. Chen; Filip K. Swirski; Hsiao-Ying Wey; Jacob Hooker; Zahi A. Fayad; Willem J. M. Mulder; Ralph Weissleder; Matthias Nahrendorf
Source
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Subject
Language
English
ISSN
2041-1723
Abstract
In vivo imaging of inflammation is crucial for detection and monitoring of many pathologies and noninvasive macrophage quantification has been suggested as a possible approach. Here Keliher et al. describe novel polyglucose nanoparticle tracers that are rapidly excreted by the kidney and with high affinity for macrophages in atherosclerotic plaques.